La microbiota intestinal humana y sus modificaciones: el poder de la dieta

Human gut microbiota and its modifiers: the power of diet

  • Bárbara Sainz Cantero Hospital de Sierrallana (Torrelavega, Cantabria, España)
Palabras clave: Microbioma gastrointestinal, Dieta, Lactancia materna, Probióticos
Key-words: Gastrointestinal microbiome, Diet, Breast feeding, Probiotics




1. Thursby E, Juge N. Introduction to the human gut microbiota. Biochemical Journal [Internet].2017 Jun;474(11):1823–36. Disponible en:
2. Sekirov I, Russell S, Antunes L. Gut microbiota in health and disease. Physiologycal Review [Internet].2010 Jul;90(3):859–904. Disponible en:
3. Shen J, Obin MS, Zhao L. The gut microbiota, obesity and insulin resistance. Molecular Aspects of Medicine [Internet]. Massachusetts: Elsevier;2013.94p. Disponible en: science/article/pii/S0098299712001288
4. Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, et al. Metagenomic analysis of the human distal gut microbiome. Science [Internet].2006 Jun;312(5778):1355–9. Disponible en: https://
5. Flint HJ, Duncan SH, Louis P. The impact of nutrition on intestinal bacterial communities. Current Opinion in Microbiology. [Internet].2017 Aug;38:59–65. Disponible en: https://www.sciencedirect. com/science/article/abs/pii/S1369527417300097
6. Singh RK, Chang HW, Yan D, Lee KM, Ucmak D, Wong K, et al. Influence of diet on the gut microbiome and implications for human health. Journal of Translational Medicine [Internet].2017;15(1):1–17. Disponible en: articles/10.1186/s12967-017-1175-y
7. He M, Shi B. Gut microbiota as a potential target of metabolic syndrome: the role of probiotics and prebiotics. Cell and Bioscience [Internet]. 2017 Oct;7:54. Disponible en: https://cellandbioscience.
8. Stinson LF, Payne MS, Keelan JA. A Critical Review of the Bacterial Baptism Hypothesis and the Impact of Cesarean Delivery on the Infant Microbiome. Frontiers in Medicine [Internet]. 2018 May;5:135. Disponible en: fmed.2018.00135/full
9. Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2007 Aug;104(34):13780–5. Disponible en: https://www.
10. Flint HJ, Duncan SH, Scott KP, Louis P. Interactions and competition within the microbial community of the human colon: links between diet and health. Environmental Microbiology [Internet].2007 May;9(5):1101–11. Disponible en: doi/full/10.1111/j.1462-2920.2007.01281.x
11. Goodrich JK, Waters JL, Poole AC, Sutter JL, Koren O, Blekhman R, et al. Human genetics shape the gut microbiome. Cell [Internet].2014 Nov;159(4):789–99. Disponible en: science/article/pii/S0092867414012410
12. Li J, Jia H, Cai X, Zhong H, Feng Q, Sunagawa S, et al. An integrated catalog of reference genes in the human gut microbiome. Nature Biotechnology [Internet]. 2014 Aug;32(8):834–41. Disponible en:
13. Le Chatelier E, Nielsen T, Qin J, Prifti E, Hildebrand F, Falony G, et al. Richness of human gut microbiome correlates with metabolic markers. Nature [Internet]. 2013 Aug;500(7464):541–6. Disponible en:
14. Swidsinski A, Weber J, Loening-Baucke V, Hale LP, Lochs H. Spatial Organization and Composition of the Mucosal Flora in Patients with Inflammatory Bowel Disease. Journal of Clinical Microbiology [Internet]. 2005 Jul 29;43(7):3380–9. Disponible en: content/43/7/3380.short
15. Macpherson AJ, McCoy KD. Stratification and compartmentalisation of immunoglobulin responses to commensal intestinal microbes. Seminars in Immunology [Internet]. 2013 Nov;25(5):358–63. Disponible en: S104453231300078X
16. Andersson AF, Lindberg M, Jakobsson H, Backhed F, Nyren P, Engstrand L. Comparative analysis of human gut microbiota by barcoded pyrosequencing. PLoS One [Internet]. 2008 Jul;3(7):2836. Disponible en: journal.pone.0002836
17. Jandhyala SM, Talukdar R, Subramanyam C, Vuyyuru H, Sasikala M, Reddy DN. Role of the normal gut microbiota. World Journal of Gastroenterology [Internet]. 2015 Aug;21(29):8836–47. Disponible en:
18. Johansson ME V, Larsson JMH, Hansson GC. The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactions. Proceedings of the National Academy of Sciences of the United States of America [Internet]. 2011 Mar;108:4659–65. Disponible: content/108/Supplement_1/4659.short
19. Swidsinski A, Loening-Baucke V, Lochs H, Hale L-P. Spatial organization of bacterial flora in normal and inflamed intestine: a fluorescence in situ hybridization study in mice. World Journal of Gastroenterology [Internet]. 2005 Feb;11(8):1131–40. Disponible en: https://
20. Saltzman JR, Russell RM. Nutritional consequences of intestinal bacterial overgrowth. Europe PMC [Internet]. 1994 Jun;20(9):523–30. Disponible en:
21. Arumugam M, Raes J, Pelletier E, Le Paslier D, Yamada T, Mende DR, et al. Enterotypes of the human gut microbiome. Nature [Internet]. 2011 May;473(7346):174–80. Disponible en:
22. Kurokawa K, Itoh T, Kuwahara T, Oshima K, Toh H, Toyoda A, et al. Comparative metagenomics revealed commonly enriched gene sets in human gut microbiomes. DNA Research [Internet]. 2007 Aug;14(4):169–81. Disponible en:
23. Den Besten G, Van Eunen K, Groen AK, Venema K, Reijngoud D-J, Bakker BM. The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. Journal of Lipid Research [Internet]. 2013 Sep;54(9):2325–40. Disponible en:
24. Kau AL, Ahern PP, Griffin NW, Goodman AL, Gordon JI. Human nutrition, the gut microbiome, and immune system: envisioning the future. Nature [Internet]. 2011 Jun 15;474(7351):327–36. Disponible en:
25. Devillard E, McIntosh FM, Duncan SH, Wallace RJ. Metabolism of Linoleic Acid by Human Gut Bacteria: Different Routes for Biosynthesis of Conjugated Linoleic Acid. Journal of Bacteriology [Internet]. 2007 Mar 5;189(6):2566–70. Disponible en:
26. Natividad JMM, Verdu EF. Modulation of intestinal barrier by intestinal microbiota: pathological and therapeutic implications. Pharmacological Research [Internet]. 2013 Mar;69(1):42–51. Disponible en: S1043661812001946
27. Hooper L V, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science [Internet]. 2012 Jun;336(6086):1268–73. Disponible en: https://science.sciencemag. org/content/336/6086/1268
28. Hooper L V. Do symbiotic bacteria subvert host immunity? Nature Reviews Microbiology [Internet]. 2009 May;7(5):367–74. Disponible en:
29. Jia W, Li H, Zhao L, Nicholson JK. Gut microbiota: a potential new territory for drug targeting. Nature reviews Drug discovery [Internet]. 2008 (7):123. Disponible en: nrd2505
30. Holmes E, Kinross J, Gibson GR, Burcelin R, Jia W, Pettersson S, et al. Therapeutic modulation of microbiota-host metabolic interactions. Science Translational Medicine [Internet]. 2012 Jun;4(137):137. Disponible en: short
31. Moya A, Ferrer M. Functional Redundancy-Induced Stability of Gut Microbiota Subjected to Disturbance. Trends in Microbiology [Internet]. 2016 May;24(5):402–13. Disponible en:
32. Mahowald MA, Rey FE, Seedorf H, Turnbaugh PJ, Fulton RS, Wollam A, et al. Characterizing a model human gut microbiota composed of members of its two dominant bacterial phyla. Proceeding of the National Academy of Sciences of the United States of America [Internet]. 2009 Apr;106(14):5859–64. Disponible en: https://www.
33. Voreades N, Kozil A, Weir TL. Diet and the development of the human intestinal microbiome. Frontiers in Microbiology [Internet]. 2014 Sep (5):1–9. Disponible en:
34. Ley RE, Backhed F, Turnbaugh P, Lozupone CA, Knight RD, Gordon JI. Obesity alters gut microbial ecology. Proceeding of the National Academy of Sciences of the United States of America [Internet]. 2005 Aug;102(31):11070–5. Disponible en:
35. Tailford LE, Crost EH, Kavanaugh D, Juge N. Mucin glycan foraging in the human gut microbiome. Frontiers in Genetics [Internet]. 2015 Mar;6:81. Disponible en:
36. Conlon MA, Bird AR. The impact of diet and lifestyle on gut microbiota and human health. Nutrients [Internet]. 2015;7(1):17–44. Disponible en:
37. Scott KP, Gratz SW, Sheridan PO, Flint HJ, Duncan SH. The influence of diet on the gut microbiota. Pharmacology Research [Internet]. 2013 Mar;69(1):52–60. Disponible en: https://www.sciencedirect. com/science/article/abs/pii/S1043661812002071
38. Aiello LP. Diabetic retinopathy and other ocular findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. American Diabetes Association [Internet]. 2014 Jan;37(1):17–23. Disponible en:
39. Martin CL, Albers JW, Pop-Busui R. Neuropathy and related findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. American Diabetes Association [Internet]. 2014 Jan;37(1):31–8. Disponible en:
40. David LA, Maurice CF, Carmody RN, Gootenberg DB, Button JE, Wolfe BE, et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature [Internet]. 2014 Jan;505(7484):559–63. Disponible en:
41. Turroni F, Peano C, Pass DA, Foroni E, Severgnini M, Claesson MJ, et al. Diversity of bifidobacteria within the infant gut microbiota. Plos One [Internet]. 2012 May;7(5):36957. Disponible en: https://journals.
42. Colodro-Conde L, Sánchez-Romera JF, Tornero-Gómez MJ, Pérez-Riquelme F, Polo-Tomás M, Ordoñana JR. Relationship Between Level of Education and Breastfeeding Duration Depends on Social Context: Breastfeeding Trends Over a 40-Year Period in Spain. Journal of Human Lactation [Internet]. 2011 Aug;27(3):272-8. Disponible en:
43. Bergstrom A, Skov TH, Bahl MI, Roager HM, Christensen LB, Ejlerskov KT, et al. Establishment of intestinal microbiota during early life: a longitudinal, explorative study of a large cohort of Danish infants. Applied and Environmental Microbiology [Internet]. 2014 May;80(9):2889–900. Disponible en:
44. Oozeer R, van Limpt K, Ludwig T, Ben Amor K, Martin R, Wind RD, et al. Intestinal microbiology in early life: specific prebiotics can have similar functionalities as human-milk oligosaccharides. The American Journal of Clinical Nutrition [Internet]. 2013 Aug;98(2):561–71. Disponible en:
45. Knol J, Boehm G, Lidestri M, Negretti F, Jelinek J, Agosti M, et al. Increase of faecal bifidobacteria due to dietary oligosaccharides induces a reduction of clinically relevant pathogen germs in the faeces of formula-fed preterm infants. Acta Paediatrica [Internet]. 2005 Oct;94(449):31–3. Disponible en: doi/abs/10.1111/j.1651-2227.2005.tb02152.x
46. Eid N, Enani S, Walton G, Corona G, Costabile A, Gibson G, et al. The impact of date palm fruits and their component polyphenols, on gut microbial ecology, bacterial metabolites and colon cancer cell proliferation. Journal of Nutritional Science [Internet]. 2014 Oct 8;(3):46. Disponible en : core/journals/journal-of-nutritional-science/article/impact-of-date-palm-fruits-and-their-component-polyphenols-on-gut-microbial-ecology-bacterial-metabolites-and-colon-cancer-cell-proliferation/1CE834125919772A67CA21561BD68952
47. Francavilla R, Calasso M, Calace L, Siragusa S, Ndagijimana M, Vernocchi P, et al. Effect of lactose on gut microbiota and metabolome of infants with cow’s milk allergy. Pediatric Allergy and Immunology [Internet]. 2012 Aug;23(5):420–7. Disponible en: https://onlinelibrary.
48. Suez J, Korem T, Zeevi D, Zilberman-Schapira G, Thaiss CA, Maza et al. Artificial sweeteners induce glucose intolerance by altering the gut microbiota. Nature [Internet]. 2014 Oct;514(7521):181–6. Disponible en:
49. Cotillard A, Kennedy SP, Kong LC, Prifti E, Pons N, Le Chatelier E, et al. Dietary intervention impact on gut microbial gene richness. Nature [Internet]. 2013 Aug;500(7464):585–8. Disponible en: https://www.
50. Furusawa Y, Obata Y, Fukuda S, Endo TA, Nakato G, Takahashi D, et al. Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells. Nature [Internet]. 2013 Dec;504(7480):446–50. Disponible en:
51. Blaut M. Gut microbiota and energy balance: role in obesity. The Proceedings of the Nutrition Society [Internet]. 2015 Aug; 75(3):227–34. Disponible en: journals/proceedings-of-the-nutrition-society/article/gut-microbiota-and-energy-balance-role-in-obesity/7D68A28E4810FE35ED5EB6A5C812C203
52. Tremaroli V, Backhed F. Functional interactions between the gut microbiota and host metabolism. Nature [Internet]. 2012 Sep;489(7415):242–9. Disponible en:
53. Wright RS, Anderson JW, Bridges SR. Propionate inhibits hepatocyte lipid synthesis. Proceedings of the Society for Experimental Biology and Medicine [Internet]. 1990 Oct;195(1):26–9. Disponible en: 43113
54. Fava F, Gitau R, Griffin BA, Gibson GR, Tuohy KM, Lovegrove JA. The type and quantity of dietary fat and carbohydrate alter faecal microbiome and short-chain fatty acid excretion in a metabolic syndrome “at-risk” population. International Journal of Obesity [Internet]. 2013 Feb;37(2):216–23. Disponible en: https://www.nature. com/articles/ijo201233
55. Caesar R, Tremaroli V, Kovatcheva-Datchary P, Cani PD, Backhed F. Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling. Cell Metabolism [Internet]. 2015 Oct;22(4):658–68. Disponible en: https://www.sciencedirect. com/science/article/pii/S1550413115003897
56. Erridge C, Attina T, Spickett CM, Webb DJ. A high-fat meal induces low-grade endotoxemia: evidence of a novel mechanism of postprandial inflammation. The American Journal of Clinical Nutrition [Internet]. 2007 Nov;86(5):1286–92. Disponible en: https://academic.
57. Everard A, Belzer C, Geurts L, Ouwerkerk JP, Druart C, Bindels LB, et al. Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesity. Proceedings of the National Academy of Sciences [Internet]. 2013 May 28;110(22):9066–71. Disponible en:
58. Davila A, Blachier F, Gotteland M, Andriamihaja M, Benetti P, Sanz Y, et al. Intestinal luminal nitrogen metabolism: role of the gut microbiota and consequences for the host. Pharmacological Research [Internet]. 2013;68(1):95–107. Disponible en:
59. Phillips SF, Pemberton JH, Shorter R. The large intestine Physiology, pathophysiology and disease. Acta Endoscópica [Internet]. 1991 Mar;21(2):18. Disponible en:
60. Swiatecka D, Narbad A, Ridgway KP, Kostyra H. The study on the impact of glycated pea proteins on human intestinal bacteria. International Journal of Food Microbiology [Internet]. 2011 Jan;145(1):267–72. Disponible en: science/article/abs/pii/S0168160511000031
61. Kim CH, Park J, Kim M. Gut Microbiota-Derived Short-Chain Fatty Acids, T Cells, and Inflammation. Immune Network [Internet]. 2014 Dec 22;14(6):277–88. Disponible en: https://synapse.koreamed. org/search.php?where=aview&id=10.4110/in.2014.14.6.277&code=0078IN&vmode=FULL
62. Cryan JF, Dinan TG. Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour. Nature Reviews Neuroscience [Internet]. 2012 Oct;13(10):701–12. Disponible en: https://
63. Hughes R, Kurth MJ, McGilligan V, McGlynn H, Rowland I. Effect of colonic bacterial metabolites on Caco-2 cell paracellular permeability in vitro. Nutrition and Cancer [Internet]. 2008 Mar;60(2):259–66. Disponible en: abs/10.1080/01635580701649644
64. Saraf K, Shashikanth MC, Priy T, Sultana N, Chaitanya NCSK. Probiotics--do they have a role in medicine and dentistry?. J Assoc Physicians India [Internet]. 2010 Aug;58:488-490,495-496. Disponible en: publication/49713063_Probiotics-Do_they_have_a_Role_in_Medicine_and_Dentistry/links/5773be9208ae1b18a7de35a1.pdf
65. Bermudez-Brito M, Plaza-Diaz J, Munoz-Quezada S, Gomez-Llorente C, Gil A. Probiotic mechanisms of action. Annals of Nutrition and Metabolism [Internet]. 2012;61(2):160–74. Disponible en:
66. Toward R, Montandon S, Walton G, Gibson GR. Effect of prebiotics on the human gut microbiota of elderly persons. Gut Microbes [Internet]. 2012 Jan;3(1):57–60. Disponible en: https://www.tandfonline. com/doi/full/10.4161/gmic.19411
67. Gibson GR, Probert HM, Loo J Van, Rastall RA, Roberfroid MB. Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutrition Research Review [Internet]. 2004 Dec;17(2):259–75. Disponible en: https://www.cambridge. org/core/journals/nutrition-research-reviews/article/dietary-modulation-of-the-human-colonic-microbiota-updating-the-concept-of-prebiotics/E445EDF28DD9C50CAE5E6BCCED5D0805
68. F Aline Gamarra Taborda, P Aline Kirjner, D Daniel De Carvalho. The therapeutic use of symbiotics. ABCD, arq. bras. cir. dig. [Internet]. 2014 Sep; 27(3):206-209.Disponible en: php?script=sci_arttext&pid=S0102-67202014000300206&lng=en.
69. Perez-Jimenez J, Neveu V, Vos F, Scalbert A. Identification of the 100 richest dietary sources of polyphenols: an application of the Phenol-Explorer database. European Journal of Clinical Nutrition [Internet]. 2010 Nov;64(3):112-20. Disponible en: https://www.nature. com/articles/ejcn2010221
70. Duenas M, Munoz-Gonzalez I, Cueva C, Jimenez-Giron A, Sanchez-Patan F, Santos-Buelga C, et al. A survey of modulation of gut microbiota by dietary polyphenols. Biomed Research International [Internet]. 2015;2015:850902. Disponible en: https://www.hindawi. com/journals/bmri/2015/850902/

Cómo citar
Sainz Cantero, Bárbara. La microbiota intestinal humana y sus modificaciones: el poder de la dieta. Nuberos Científica. 2019; 3(28): 12-1. Disponible en: [acceso: 23/01/2020]
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