Disruptores endocrinos ambientales y resultados reproductivos femeninos: una revisión bibliográfica

Environmental endocrine disruptors and female reproductive outcomes: a literature review

  • Macarena Sánchez Díaz Hospital Universitario Miguel Servet (Zaragoza, España)
  • Lorena Contreras López Hospital Doctor José Molina Orosa (Lanzarote, España)
Palabras clave: Disruptores endocrinos, Fertilidad, Bisfenol A, Ftalatos, Pesticidas, Parabenos
Key-words: Endocrine disrupting chemicals, Fertility, Bisphenol A, Phthalates, Pesticides, Parabens




1. Valls-Llobet, C. Sesgos de género en medio ambiente y salud. En: Puleo, A, editor. Ecología y género en diálogo interdisciplinar; 2015, p.21-35.
2. Rattan S, Zhou C, Chiang C, Mahalingam S, Brehm E, Flaws JA. Exposure to endocrine disruptors during adulthood: conse-quences for female fertility. Int J Endocrinol. 2017; 233 (3): R109-R129
3. Hipwell A.E, Kahn L.G, Factor-Litvak P, Porucznik C.A, Siegel E.L, Fichorova R.N. Exposure to non-persistent chemicals in consumer products and fecundability: a systematic review. Hum. Reprod. Update. 2019; 25 (1): 51-71.
4. Mínguez-alarcón L, Gaskins A.J. Female exposure to endocrine disrupting chemicals and fecundity: a review. Curr. Opin. Obs-tet. Gynecol. 2017; 29 (4): 202
5. Ziv-gal A, Flaws J.A. Evidence for bisphenol A-induced female infertility: a review (2007–2016). Fertil. Steril. 2016; 106 (4): 827-856.
6. Chiang C, Mahalingam S, Flaws J.A. Environmental contaminants affecting fertility and somatic health. Semin. Reprod. Med. Thieme Medical Publishers. 2017. p. 241-249
7. Costa EM, Spritzer PM, Hohl A, Bachega TA. Effects of endocrine disruptors in the development of the female reproductive tract. Arq Bras Endocrinol Metabol. 2014;58(02):153–161
8. Souter I, Smith KW, Dimitriadis I, et al. The association of bisphenol-A urinary concentrations with antral follicle counts and other measures of ovarian reserve in women undergoing infertility treatments. Reprod Toxicol. 2013;42:224–231
9. Buck Louis GM, Sundaram R, Sweeney AM, Schisterman EF, Maisog J, Kannan K. Urinary bisphenol A, phthalates, and cou-ple fecundity: the Longitudinal Investigation of Fertility and the Environment (LIFE) Study. Fertil Steril. 2014;101(05):1359–1366
10. Mínguez-Alarcón L, Messerlian C, Bellavia A, Gaskins AJ, Chiu YH, Ford JB, Williams PL. Urinary concentrations of bis-phenol A, parabens and phthalate metabolite mixtures in relation to reproductive success among women undergoing in vitro fertilization. Environ. Int. 2019; 126: 355-362
11. Mok-Lin E, Ehrlich S, Williams PL, Petrozza J, Wright DL, Calafat AM, et al. Urinary bisphenol A concentrations and ovarian response among women undergoing IVF. In J Androl. 2010; 33(2):385–93.
12. Ehrlich S, Williams PL, Missmer SA, Flaws JA, Ye X, Calafat AM, et al. Urinary bisphenol A concentrations and early re-productive health outcomes among women undergoing IVF. Hum Reprod. 2012; 27(12):3583–92.
13. Ehrlich S, Williams PL, Missmer SA, Flaws JA, Berry KF, Calafat AM, et al. Urinary bisphenol A concentrations and implan-tation failure among women undergoing in vitro fertilization. Environ Health Perspect. 2012; 120(7):978–83.
14. Minguez-Alarcon L, Gaskins AJ, Chiu YH, Williams PL, Ehrlich S, Chavarro JE, et al. Urinary bisphenol A concentrations and association with in vitro fertilization outcomes among women from a fertility clinic. Hum Reprod. 2015; 30(9):2120–8.
15. Chavarro JE, Minguez-Alarcon L, Chiu YH, Gaskins AJ, Souter I, Williams PL, et al. Soy Intake Modifies the Relation Bet-ween Urinary Bisphenol A Concentrations and Pregnancy Outcomes Among Women Undergoing Assisted Reproduction. J Clin Endocrinol Metab. 2016; 101(3):1082–90.
16. Minguez-Alarcon L, Gaskins AJ, Chiu YH, Souter I, Williams PL, Calafat AM, et al. Dietary folate intake and modification of the association of urinary bisphenol A concentrations with in vitro fertilization outcomes among women from a fertility clinic. Reprod Toxicol. 2016; 65:104–12.
17. Bloom MS, Kim D, Vom Saal FS, Taylor JA, Cheng G, Lamb JD, et al. Bisphenol A exposure reduces the estradiol response to gonadotropin stimulation during in vitro fertilization. Fertil Steril. 2011; 96:672–7. e2
18. Peretz J, Vrooman L, Ricke WA, et al. Bisphenol A and reproductive health: update of experimental and human evidence, 2007–2013. Environ Health Perspect 2014;122(08):775–786
19. Velez MP, Arbuckle TE, Fraser WD. Female exposure to phenols and phthalates and time to pregnancy: the Maternal-Infant Research on Environmental Chemicals (MIREC) Study. Fertil Steril. 2015; 103(4):1011–20. e2.
20. Jukic AM, Calafat AM, McConnaughey DR, Longnecker MP, Hoppin JA, Weinberg CR, et al. Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss. Environ Health Perspect. 2016; 124(3):321–8.
21. Gonsioroski A; Mourikes VE, Flaws JA. Endocrine Disruptors in Water and Their Effects on the Reproductive System. Int. J. Mol. Sci. 2020; 21(6): 1929
22. Dodge L, Williams P, Williams M, Missmer S, Souter I, Calafat A, Hauser R, Team ES. Associations between paternal urinary phthalate metabolite concentrations and reproductive outcomes among couples seeking fertility treatment. Reprod Toxicol 2015;58:184–193.
23. Hauser R, Gaskins AJ, Souter I, Smith KW, Dodge LE, Ehrlich S, et al. Urinary Phthalate Metabolite Concentrations and Reproductive Outcomes among Women Undergoing in Vitro Fertilization: Results from the EARTH Study. Environ Health Pers-pect. 2016; 124(6):831–9
24. Messerlian C, Souter I, Gaskins AJ, et al.; Earth Study Team. Urinary phthalate metabolites and ovarian reserve among wo-men seeking infertility care. Hum Reprod 2016;31(01):75–83
25. Specht IO, Bonde JP, Toft G, Lindh CH, Jönsson BA, Jørgensen KT. Serum phthalate levels and time to pregnancy in couples from Greenland, Poland and Ukraine. PLoS One. 2015;10(03):e0120070
26. Kay VR, Bloom MS, Foster WG. Reproductive and developmental effects of phthalate diesters in males. Crit Rev Toxicol. 2014; 44(06):467–498
27. Annamalai J, Namasivayam V. Endocrine disrupting chemicals in the atmosphere: Their effects on humans and wildlife. Environ Int 2015;76:78–97
28. Toft G, Thulstrup AM, Jonsson BA, Pedersen HS, Ludwicki JK, Zvezday V, Bonde JP. Fetal loss and maternal serum levels of 2,2′,4,4′,5,5′-hexachlorbiphenyl (CB-153) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (p,p’-DDE) exposure: a cohort study in Greenland and two European populations. Environ Health. 2010;9:22
29. Chevrier C, Warembourg C, Gaudreau E, et al. Organochlorine pesticides, polychlorinated biphenyls, seafood consumption, and time-to-pregnancy. Epidemiology 2013;24(02):251–260
30. Smith KW, Souter I, Dimitriadis I, Ehrlich S, Williams PL, Calataf, AM, Hauser R. Urinary paraben concentrations and ovari-an aging among women from a fertility center. Environ. Health Perspect. 2013; 121(11-12): 1299-1305.
31. Mínguez-Alarcón L, Chiu YH, Messerlian C, et al.; EARTH Study Team. Urinary paraben concentrations and in vitro fertili-zation outcomes among women from a fertility clinic. Fertil Steril 2016; 105(03):714–721
32. Smarr MM, Sundaram R, Honda M, Kannan K, Buck Louis GM. Urinary Concentrations of Parabens and Other Antimicrobial Chemicals and Their Association with Couples’ Fecundity. Environ Health Perspect. 2017; 125(4):730-36.

Cómo citar
Sánchez Díaz, Macarena; Contreras López, Lorena. Disruptores endocrinos ambientales y resultados reproductivos femeninos: una revisión bibliográfica. Evidentia. 2020; 17: e12873. Disponible en: http://ciberindex.com/c/ev/e12873 [acceso: 23/10/2020]
Revisión Bibliográfica


Normas y uso de comentarios

Hay un total de 0 comentarios


Para enviar un comentario, rellene los campos situados debajo. Recuerde que es obligatorio indicar un nombre y un email para enviar su comentario (el email no sera visible en el comentario).